I've heard many people (myself included) joke that the best solution to a problem is to do a "FORMAT C:"
Growing up in the around computers, it was one of the most feared commands I could think of typing.
Armed with the benefit of a Windows XP Virtual PC image, I thought I'd actually confront my childhood fear:
What a let down! It won't even let you do it. I even tried a forced quick format.
Alas, another myth broken. I guess there's always "rm -rf /"
UPDATE: Check out Jonathan's post where he was much more persistent in his attempt.